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. 2022 Jun 1;5(2):459–471. doi: 10.20517/cdr.2022.07

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© The Author(s) 2022.

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Signaling pathways regulating CSCs and the use of inhibitors in suppressing these pathways. These molecules thereof could be developed as potential therapeutics. The denotes in the figure are: Hedgehog signaling pathway (HH), notch intracellular domain (NICD), phosphorylation (P), smoothened (SMO), Wnt signaling pathways (Wnt), nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkBα), RELA Proto-Oncogene (RelA), Frizzled (FZD), casein kinase I (CKI), Axin (AXIN), APC Regulator of WNT Signaling Pathway (APC), Dishevelled (Dvl), Glycogen Synthase Kinase (GSK), IkappaB Kinase (IKK).