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. 2022 Jun 1;5(2):459–471. doi: 10.20517/cdr.2022.07

Table 1.

Prostate cancer stem cells markers

Pathways Markers names Gene symbol Ref.
Tumor progression KIT proto-oncogene, receptor tyrosine kinase CD117/c-kit [43,54-56]
Prominin 1 CD133
Indian blood group CD44
α2β1 integrin ITGB1
Integrin Subunit Alpha 6 α6 integrin
C-X-C motif chemokine receptor 4 CXCR4
Epithelial cell adhesion molecule EPCAM
Cytokeratin 5 KRT5
Kallikrein related peptidase 3 KLK3/PSA
Tumor-associated calcium signal transducer 2 Trop2
Activated leukocyte cell adhesion molecule ALCAM
Aldehyde dehydrogenase 1 family member A1 ALDH1
Transglutaminase 2 TG2
Enhancer of zeste 2 polycomb repressive complex 2 subunit EZH2
Metastatic colonization and
growth
KIT proto-oncogene, receptor tyrosine kinase CD117/c [43,56]
C-X-C motif chemokine receptor CXCR4
Epithelial cell adhesion molecule EPCAM
E-cadherin/ cadherin 1 CDH1
Indian blood group CD44
Enhancer of zeste 2 polycomb repressive complex 2 subunit EZH2
Recurrence and therapeutic
resistance
KIT proto-oncogene, receptor tyrosine kinase CD117/c-kit [43,54-56]
α2β1 integrin ITGB1
Integrin subunit alpha 6 ITGA6
E-cadherin/ cadherin 1 CDH1
Epithelial cell adhesion molecule EPCAM
C-X-C motif chemokine receptor 4 CXCR4
Enhancer of zeste 2 polycomb repressive complex 2 subunit EZH2
Aldehyde dehydrogenase 1 family member A1 ALDH1
Transglutaminase 2 TG2
Activated leukocyte cell adhesion molecule CD166/ALCAM
Kallikrein related peptidase 3 KLK3/PSA
Androgen receptor splice variant 7 AR-V7
ATP binding cassette subfamily G member 2 (junior blood group) ABCG2
Self-renewal capacity Prominin 1 CD133 [43,55]
Cytokeratin 5 KRT5
Kallikrein related peptidase 3 KLK3/PSA
Aldehyde dehydrogenase 1 family member A1 ALDH1
Activated leukocyte cell adhesion molecule CD166/ALCAM
C-X-C motif chemokine receptor 4 CXCR4
Tumor-associated calcium signal transducer 2 Trop2
Integrin subunit alpha 6 α6 integrin
α2β1 integrin ITGB1
Indian blood group CD44
Stemness gene expression Prominin 1 CD133 [43,54]
Indian blood group CD44
E-cadherin/ cadherin 1 CDH1
Kallikrein related peptidase 3 KLK3/PSA
Aldehyde dehydrogenase 1 family member A1 ALDH1
Enhancer of zeste 2 polycomb repressive complex 2 subunit EZH2