Table 1.
Pathways | Markers names | Gene symbol | Ref. |
Tumor progression | KIT proto-oncogene, receptor tyrosine kinase | CD117/c-kit | [43,54-56] |
Prominin 1 | CD133 | ||
Indian blood group | CD44 | ||
α2β1 integrin | ITGB1 | ||
Integrin Subunit Alpha 6 | α6 integrin | ||
C-X-C motif chemokine receptor 4 | CXCR4 | ||
Epithelial cell adhesion molecule | EPCAM | ||
Cytokeratin 5 | KRT5 | ||
Kallikrein related peptidase 3 | KLK3/PSA | ||
Tumor-associated calcium signal transducer 2 | Trop2 | ||
Activated leukocyte cell adhesion molecule | ALCAM | ||
Aldehyde dehydrogenase 1 family member A1 | ALDH1 | ||
Transglutaminase 2 | TG2 | ||
Enhancer of zeste 2 polycomb repressive complex 2 subunit | EZH2 | ||
Metastatic colonization and growth |
KIT proto-oncogene, receptor tyrosine kinase | CD117/c | [43,56] |
C-X-C motif chemokine receptor | CXCR4 | ||
Epithelial cell adhesion molecule | EPCAM | ||
E-cadherin/ cadherin 1 | CDH1 | ||
Indian blood group | CD44 | ||
Enhancer of zeste 2 polycomb repressive complex 2 subunit | EZH2 | ||
Recurrence and therapeutic resistance |
KIT proto-oncogene, receptor tyrosine kinase | CD117/c-kit | [43,54-56] |
α2β1 integrin | ITGB1 | ||
Integrin subunit alpha 6 | ITGA6 | ||
E-cadherin/ cadherin 1 | CDH1 | ||
Epithelial cell adhesion molecule | EPCAM | ||
C-X-C motif chemokine receptor 4 | CXCR4 | ||
Enhancer of zeste 2 polycomb repressive complex 2 subunit | EZH2 | ||
Aldehyde dehydrogenase 1 family member A1 | ALDH1 | ||
Transglutaminase 2 | TG2 | ||
Activated leukocyte cell adhesion molecule | CD166/ALCAM | ||
Kallikrein related peptidase 3 | KLK3/PSA | ||
Androgen receptor splice variant 7 | AR-V7 | ||
ATP binding cassette subfamily G member 2 (junior blood group) | ABCG2 | ||
Self-renewal capacity | Prominin 1 | CD133 | [43,55] |
Cytokeratin 5 | KRT5 | ||
Kallikrein related peptidase 3 | KLK3/PSA | ||
Aldehyde dehydrogenase 1 family member A1 | ALDH1 | ||
Activated leukocyte cell adhesion molecule | CD166/ALCAM | ||
C-X-C motif chemokine receptor 4 | CXCR4 | ||
Tumor-associated calcium signal transducer 2 | Trop2 | ||
Integrin subunit alpha 6 | α6 integrin | ||
α2β1 integrin | ITGB1 | ||
Indian blood group | CD44 | ||
Stemness gene expression | Prominin 1 | CD133 | [43,54] |
Indian blood group | CD44 | ||
E-cadherin/ cadherin 1 | CDH1 | ||
Kallikrein related peptidase 3 | KLK3/PSA | ||
Aldehyde dehydrogenase 1 family member A1 | ALDH1 | ||
Enhancer of zeste 2 polycomb repressive complex 2 subunit | EZH2 |