Skip to main content
. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: J Neurogenet. 2021 Jun 7;35(4):358–369. doi: 10.1080/01677063.2021.1931180

Figure 3. Systemic administration of mGluR1 PAM restores DHPG-LTD.

Figure 3.

A. PAM injection schedule. Six daily in vivo administration of DMSO or PAM (4 mg/kg, IP) was given 12 hours after cocaine injection on indicated days during cocaine injection regimen.

B. Lack of effect of DMSO injections on DHPG-LTD in cocaine-treated mice. N = 8 cells from 4 mice.

C. Rescue of DHPG-LTD in PAM-injected, cocaine-treated mice. N = 6 cells from 3 mice.

D. Summary of DHPG-LTD in difference conditions. Data for saline are replotted from Figure 1 for direct comparisons. ** p < 0.01, unpaired Student’s t-test.