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. Author manuscript; available in PMC: 2023 Jan 27.
Published in final edited form as: J Med Chem. 2021 Oct 20;65(2):1370–1383. doi: 10.1021/acs.jmedchem.1c00848

Scheme 2.

Scheme 2.

Preparation of allosteric binding motifs a

aReagents and conditions: (i) H2SO4, 60 °C, 42 %; (ii) Sn, HCl/AcOH, 50 °C, 85 %; (iii) Ac2O, 4-DMAP, rf, 75 %; (iv) TBDMS-Cl, Et3N, ACN, rt, 98 %/46 %.