. 2022 Jul 4;12(7):e052630. doi: 10.1136/bmjopen-2021-052630

Table 3.

Association between serum hsCRP level and cardiovascular disease mortality by gender and NCD_history at recruitment

	Cardiovascular disease mortality					Healthy subjects at recruitment					Subjects with NCD_history at recruitment
	E	MR	aHR	HR_1year	HR_2years	E	MR	aHR	HR_1year	HR_2years	E	MR	aHR	HR_1year	HR_2years
Total
≤1.00	167	3.1	Ref	Ref	Ref	58	1.7	Ref	Ref	Ref	109	5.5	Ref	Ref	Ref
1.01–2.00	79	5.8	1.35	1.37	1.23	18	2.8	1.19	1.15	0.94	64	8.4	1.42	1.46	1.36
2.01–3.00	42	10.0	2.06	2.05	2.02	6	3.3	1.47	1.54	1.46	36	15.0	2.28	2.25	2.26
3.01–10.0	39	7.7	1.45	1.38	1.44	8	3.7	1.44	1.50	1.70	31	1.08	1.48	1.37	1.40
>10.0	13	9.6	1.81	1.76	1.59	3	4.6	2.02	2.10	1.58	10	14.3	1.85	1.74	1.68
P trend			0.001	0.002	0.004			0.130	0.100	0.162			0.001	0.006	0.009
Men
≤1.00	89	5.5	Ref	Ref	Ref	25	2.7	Ref	Ref	Ref	64	8.9	Ref	Ref	Ref
1.01–2.00	45	8.3	1.33	1.32	1.25	12	4.8	1.30	1.22	1.22	33	11.3	1.31	1.33	1.33
2.01–3.00	30	17.6	2.70	2.67	2.53	3	4.2	1.31	1.37	1.37	27	27.3	3.05	2.99	2.99
3.01–10.0	24	11.4	1.43	1.36	1.46	6	6.6	1.70	1.79	1.79	18	15.1	1.42	1.21	1.21
>10.0	8	13.0	1.90	2.02	1.70	3	10.6	3.42	3.61	3.61	5	15.0	1.59	1.62	1.62
P trend			0.002	0.003	0.009			0.053	0.038	0.062			0.015	0.027	0.047
Women
≤1.00	78	2.1	Ref	Ref	Ref	33	1.3	Ref	Ref	Ref	45	6.3	Ref	Ref	Ref
1.01–2.00	34	4.2	1.41	1.46	1.25	6	1.6	1.09	1.13	0.62	28	9.6	1.60	1.66	1.58
2.01–3.00	12	4.8	1.26	1.30	1.44	3	2.7	1.65	1.70	1.86	9	9.1	1.17	1.20	1.39
3.01–10.0	15	5.1	1.51	1.45	1.44	2	1.6	1.06	1.07	1.14	13	10.9	1.75	1.64	1.65
>10.0	5	6.8	1.72	1.35	1.45	0	–	–	–	–	5	15.0	2.51	1.91	2.07
P trend			0.092	0.177	0.168			0.940	0.998	0.922			0.035	0.092	0.078

aHR: adjusted for age, gender, education, job, marital status, BMI, NCD_history, smoking, alcohol consumption and exercise.

HR_1year: aHR after excluding subjects who died within 1-year follow-up time.

HR_2years: aHR after excluding subjects who died within 2-year follow-up time.

aHR, adjusted hazard ratio; BMI, body mass index; E, number of death; hsCRP, high-sensitivity C reactive protein; MR, mortality rate (10 000 person-years); NCD_history, non-communicable disease history; Ref, reference.