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. 2022 Jun 21;10:901093. doi: 10.3389/fcell.2022.901093

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Copyright © 2022 Zhang, Fang, Lou, Ye, Shen, Chen, Amin, Botchway and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TNF-α immunofluorescence showed that the expression of TNF-α protein in the hippocampus and frontal cortex of SHR was increased compared with that of WKY group, bar = 100 μm. (A) The expression of TNF-α in the hippocampus CA1 region of WKY and SHR. (B) the expression of TNF-α in the frontal cortex of WKY and SHR. (C) The mean intensity of TNF-α was upregulated in the SHR at each age-matched group in the hippocampus and frontal cortex. *p < 0.05 versus age-matched WKY control. **p < 0.01, versus age-matched WKY control. The values represent mean ± SD.