Table 4.
Assessment of rFcRn binding to albumins and lgGs
| Ligand | rFcRn pH 6 Kd, µM | hFcRn pH 6 Kd, µM | mFcRn pH 6 Kd, µM |
|---|---|---|---|
| Albumins | |||
| Rat | 11.6 | ∼1.1 | SB |
| Rabbit | 11.8 | ||
| Human | >100 | 4.6–5.2 | ∼86 |
| Human | WB | 1.1 | WB |
| Porcine | >100 | >50 | |
| Mouse | >100 | 0.8 | 9.3–SB |
| Bovine | >100 | ||
| Sheeo | >100 | ||
| Rhesus | WB | ||
| IgGs | |||
| Rat | 1.8 | ∼0.45 | |
| Rat lqG2a | 0.014 | NB | |
| Rabbit | 0.19 | SB | SB |
| Human | 0.63 | 0.70 | 0.265 |
| 0.03 | 0.09 | ||
| Human | 0.05 | 2.35 | 1.2 |
| Human laG1 | 0.63 | 0.082 | |
| Bovine | 1.5 | WB | SB |
| Mouse | >100 | WB | ∼0.01 |
| Mouse lqG1 | >50 | 0.75 | |
| Mouse lqG2a | 0.019 | NB | 0.025 |
| Rat and Mouse | |||
| lqGs | ∼0.05 | ||
FcRn, neonatal Fc receptor; hFcRn, human FcRn; Kd, dissociation coefficient; mFcRn, mouse FcRn; NB, no binding; rFcRn, rat FcRn; SB, strong binding; WB, weak binding.