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. 2022 Jun 13;16(6):e0010485. doi: 10.1371/journal.pntd.0010485

Fig 7. Association of 500 bp C-terminal of TE deletion with a lack of immune response.

Fig 7

(A-C) RNA-seq analysis of the whole-genome transcript profiles of mice infected with all strains and PBS. (A) PCA showed the Δpks1-TE-C500 group was relatively similar to the PBS group on the 3rd and 7th day. (B) Heatmap of the RNA-seq data for all groups. (C) Heatmap of gene expression in neutrophil chemotaxis in all groups. (D) Specific proinflammatory cytokines and neutrophil chemokines were significantly reduced in Δpks1-TE-C500 group on the 3rd, 7th and 14th day after injection, compared with wild-type group. Statistical significance was determined by two-tailed t-test (**P<0.01; ***P<0.001; ****P<0.0001).