Figure 2.

Mechanical properties of liposomal hydrogels are tuned by liposome concentration in the hydrogel. All measurements were performed on hydrogels composed of 1%, 4%, and 10% 50 nm extruded liposome content (by weight). All hydrogel formulations were 2% HPMC-C₁₂ by weight. (A) Oscillatory shear rheology measurements indicate increased liposome content increases G’ and G”. (B) G’ and G” values at 10 rad/s, data represent mean and SEM of 2 replicate batches. (C) Strain controlled oscillatory shear rheology. (D) Yield strain values extracted from strain amplitude response data. (E) Flow rheology overlay showing low to high stress-sweep behavior (solid circles and high to low flow sweep (empty circles). (F) Yield stress values extracted from flow rheology data. Statistical comparisons were made using a one-way ANOVA, and the false discovery rate (FDR) was controlled at 5% using the Benjamini, Krieger, and Yekutieli method.