Table 3.
Association of polypharmacy/PIM variables and potential drug-drug and drug-cancer treatment interactions.
| Variable | Definition | Any potential drug-drug interactions | Any potential major drug-drug interaction | Any potential major drug-cancer treatment interaction | |||
|---|---|---|---|---|---|---|---|
| POR | 95% CI | POR | 95% CI | POR | 95% CI | ||
| Polypharmacya | < 5 meds | Ref. | — | — | — | — | — |
| ≥ 5 meds | 19.58 | 12.78-28.71 | 5.64 | 3.55-8.95 | 1.89 | 0.91-3.94 | |
| Polypharmacy (prescription only) | <5 meds | Ref. | — | — | — | — | — |
| ≥5 meds | 17.11 | 10.11-28.94 | 3.21 | 2.25-4.57 | 1.49 | 0.78-2.85 | |
| Excessive Polypharmacya | < 10 meds | Ref. | — | — | — | — | — |
| ≥ 10 meds | 29.71 | 7.26-121.56 | 6.74 | 4.32-10.49 | 1.84 | 0.85-4.00 | |
| PIMa | No | Ref. | — | — | — | — | — |
| Yes | 3.19 | 2.30-4.42 | 1.58 | 1.10-2.27 | 1.23 | 0.62-2.43 | |
Includes both prescription and nonprescription medications.
Abbreviations: CI, confidence interval; PIM, potentially inappropriate medications; POR, prevalence odds ratio.
Bolded values are statistically significant.