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. 2022 Apr 24;27(7):e589–e596. doi: 10.1093/oncolo/oyac067

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Forest plot of PFS among ASCT-ineligible patients with high-risk NDMM from MAIA and ALCYONE, separately and pooled.

Abbreviations: ASCT, autologous stem cell transplant; CI, confidence interval; HR, hazard ratio; NDMM, newly diagnosed multiple myeloma; PFS, progression-free survival.

^aFor the pooled analysis, a multivariate stratified Cox regression analysis was used to calculate adjusted HR, with the study identifier as the stratification factor. HR was adjusted for cytogenetic abnormalities [ie, del(17p), t(4, 14), 4(14, 16)], baseline Eastern Cooperative Oncology Group performance status, International Staging System stage, type of multiple myeloma (ie, IgG vs. non-IgG), and renal impairment (defined as creatinine clearance <60 mL/minute).