Table 1.
Percent mammographic density and absolute density change at three time points compared with baseline for the 33 women completing at least 6 months of medication, subdivided per dose arm.
| Characteristics | Month 0 | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Number of women having a mammogram | 33 | 33 | 33 | 33 |
| All women (N = 33) | ||||
| Age at baseline, mean (SD) | 62.1 (SD 9.1) | |||
| Postmenopausal, % | 82 | |||
| Mammography density, mean (95% CI) | 17.6 (12.3-22.8) | 15.8 (11.0-22.5) | 15.3 (10.5-20.1) | 14.6 (10.3-19.0) |
| Absolute density difference, mean (95% CI) | Ref. | −1.8 (−3.3 to −0.2) | −2.2 (−4.2 to −0.3) | −2.9 (−5.0 to −0.9) |
| Women in the 10 mg arm (N = 19) | ||||
| Age at baseline, mean (SD) | 60.0 (SD 8.9) | |||
| Postmenopausal, % | 68 | |||
| Mammography density, mean (95% CI) | 15.9 (8.9-22.8) | 13.7 (7.4-20.0) | 12.7 (6.4-19.0) | 12.6 (6.8-18.3) |
| Absolute density difference, mean (95% CI) | Ref. | −2.1 (−4.2 to −0.1) | −3.1 (−5.7 to −0.5) | −3.3 (−6.1 to- −0.5) |
| Women in the 20 mg arm (N = 14) | ||||
| Age at baseline, mean (SD) | 65.1 (SD 5.3) | |||
| Postmenopausal, % | 100 | |||
| Mammographic density, mean (95% CI) | 19.9 (11.8-27.9) | 18.5 (11.2-25.9) | 18.8 (11.5-26.2) | 17.4 (10.7-24.1) |
| Absolute density difference, mean (95% CI) | Ref. | −1.3 (−3.7 to -1.1) | −1.0 (-4.1-2.0) | −2.5 (−5.7 to 0.8) |
Abbreviations: CI, confidence interval; SD, standard deviation.