Table 1.

List of anti-lung cancer agents targeting sphingolipid metabolism.

Name	Target or activity	Cell type	Function	Refs
FTY720	S1PR1; I2PP2A	A549 lung adenocarcinoma cells	Inhibitor	[68, 77]
ABC294640	SphK2; DES	NSCLC cell lines	Inhibitor	[74]
Myriocin	SPT	Human lung adenocarcinoma cell line (HCC4006);	Inhibitor	[23]
N-((3S,4R)-1-((8-chloroquinoxalin-6-yl)carbonyl)-3-phenylpiperidin-4-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide	SPT	A549 lung adenocarcinoma cells; human lung adenocarcinoma cell line (HCC4006); NCI-H460 human lung cancer; NCI-H522 human lung cancer	Inhibitor	[24]
Tetrahydropyrazolopyridine; 3-phenylpiperidine	SPT	Human lung adenocarcinoma cell line (HCC4006)	Inhibitors	[78]
Antifolate methotrexate	CesS	A549 lung adenocarcinoma cells	Indirect activator	[79]
N, N-Dimethyl-D-erythro-sphingosine (DMS)	SphK1	A549 lung adenocarcinoma cells	Inhibitor	[80]
Ellagic acid	SphK1	A549 lung adenocarcinoma cells	Inhibitor	[81]
Harmaline	SphK1	A549 lung adenocarcinoma cells	Inhibitor	[82]
PGR260	SphK1	A549 and NCI-H1944 cell lines	Inhibitor	[83]
GDC-0349	SphK1	A549 lung adenocarcinoma cells	Inhibitor	[84]
miR-338-3p	SphK2	A549 and H1299 cell lines	Downregulation	[76]
NVP-231	CerK	NCI-H358 human lung cancer cell lines	Inhibitor	[22]