Figure 2.

The miR-1224-5p agomir aggravates LPS-induced ALI in mice. (a) Mice were intravenously injected with the miR-1224-5p agomir (30 mg/kg/day) or AgNC for 3 consecutive days and then exposed to LPS (5 mg/kg) for 12 h, and the levels of miR-1224-5p in lungs were measured. (b)–(f) Pulmonary function was detected. (g, h) Arterial blood gas analysis of PaO₂, PaCO₂, and HCO₃⁻. (i) Lung wet to dry ratio. (j) LDH activities in lungs. (k) Total protein concentrations in BALF. Data represent the means ± SD (n = 6 per group). ∗P < 0.05 versus the matched group.