Fig. 3.

Effect of FXR activation on liver inflammation. Activation arrows are indicated in black and inhibition arrows in red. AP-1: activator protein 1; CA: cholic acid; CDCA: chenodeoxycholic acid; CYP450: cytochrome P450 family 7 subfamily A member 1; DCA: deoxycholic acid; FGF19: fibroblast growth factor 19; FXR: farnesoid X receptor; LCA: lithocholic acid; MDSCs: myeloid-derived suppressor cells; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3: NOD-, LRR- and pyrin domain–containing protein 3; SHP: small heterodimer partner; SOCS3: suppressor of cytokine signaling 3