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. 2022 Jul 5;13:3875. doi: 10.1038/s41467-022-31479-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Immunofluorescence images of F4/80 (yellow), CD206 (green), and CD80 (violet) in the infected tissues after treatment. Scale bar is 400 μm. Percentage of CD80⁺ (b) and CD206⁺ (c) area to total F4/80⁺ area calculated from the immunofluorescence images (n = 10 biologically independent samples; mean ± SD). Secretion levels of IL-12p70 (d) and IL-4 (e) in the infected tissues after treatment (n = 5 biologically independent samples; mean ± SD). f Expression levels of CD80 and CD206 in the infected tissues determined by western blotting after treatment. g Heat map of the relative expression of CD80 and CD206 in the infected tissues compared to the PBS group calculated from western blotting results. Secretion levels of M1 macrophage-relative cytokines (h) and M2 macrophage-relative cytokines (i) in the serums isolated from mice after treatment (n = 5 biologically independent samples; mean ± SD). All statistical significance was analyzed via one-way ANOVA with a Tukey post-hoc test. Source data are provided as a Source Data file.