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. 2022 Jul 5;13:3875. doi: 10.1038/s41467-022-31479-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Schematic illustration of the HCM gel in situ formed on bacterial biofilm infected wounds. b SEM image of the HCM gel. Inset: photograph of HCM gel. c CLSM images of the HCM gel, in which the fibrinogen was labeled with fluorescein isothiocyanate (FITC, blue). Cumulative release profile of Ce6 (d) and MNZ (e) from the HCM gel incubated with or without Hyal under different pH conditions (n = 3 independent samples; mean ± SD). Fluorescence images (f) and fluorescence intensity (g) of normal wounds and wounds with MRSA biofilm infection in diabetic mice after treatment with HCM gel at different time points (n = 3 biologically independent animals from f; mean ± SD). Statistical significance was analyzed via one-way ANOVA with a Tukey post-hoc test. Three independent experiments were performed and representative results are shown in b and c. Source data are provided as a Source Data file.