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. 2022 Jul 5;12:267. doi: 10.1038/s41398-022-02027-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Network plot and league table of comparison of pharmacological treatment strategies in treatment of patients with antipsychotic-induced hyperprolactinemia less than 50 ng/ml; B network plot and league table of comparison of pharmacological treatment strategies in treatment of patients with antipsychotic-induced hyperprolactinemia more than 50 ng/ml; C network plot and league table of comparison of pharmacological treatment strategies in treatment of patients with antipsychotic-induced hyperprolactinemia more than 100 ng/ml. ARI_5 mg adjunctive 5 mg aripiprazole, ARI_10 mg adjunctive 10 mg aripiprazole, ARI_more_10 mg adjunctive more than 10 mg aripiprazole, MET adjunctive metformin, PGD adjunctive Peony-Glycyrrhiza decoction, switch_ARI_fixed_im switching to ARI with fixed dosage and reducing the previous antipsychotic immediately, switch_ARI_fixed_ta switching to ARI with fixed dosage and reducing the previous antipsychotic in tardation, switch_ARI_ti_ta switching to ARI in titration and reducing the previous antipsychotic in tardation, VitB6 adjunctive high-dose vitamin B6. The color of each cell indicates the certainty of evidence according to the Grading of Recommendations Assessment, Development, and Evaluation. Red color refers to very low certainty of evidence, yellow color refers to low certainty of evidence, green color refers to moderate certainty of evidence, blue color refers to high certainty of evidence. The significant outcomes were shown in bold.