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. 2022 Jul 5;12:11349. doi: 10.1038/s41598-022-15027-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Motifs in the wiring diagram. (A) These four subgraphs that appear in the connectome have specific biological functions. Although the biological significance of these motifs was previously hypothesized, enumerating all subgraphs can identify additional essential motifs. (B) Here, we see six isomorphic subgraphs of size 3. The node colors do not represent labels but rather correspond to the bijection that preserves edges. The boxed subgraph is the canonical form where the string (bottom right) corresponding to the adjacency matrix (bottom left) is minimized.