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. 2022 Jun 14;54(6):711–719. doi: 10.1038/s12276-022-00785-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Among the three different endothelial subtypes, arterial, capillary and venous, only venous endothelial cells respond to angiogenic factors released from the hypoxic area. Initial sprouts from preexisting veins do not have a lumen for blood circulation, and the process of lumenization follows vascular stalk formation.