Table 2.

Associations between AUD and PRS_gene, PRS_intergenic, and PRS_all in AA and EA.

		PRSgene				PRSintergenic				PRSall
Population	Target dataset	Beta	SE	P-value	# Variants	Beta	SE	P-value	# Variants	Beta	SE	P-value	# Variants
AA	Alla	0.17	0.03	3.55E−08	858	0.03	0.03	0.32	675	0.12	0.03	9.42E−05	1,126,428
	COGA	0.15	0.04	9.67E−04	858	0.02	0.04	0.61	675	0.06	0.04	0.16	1,126,428
	SAGE	0.18	0.07	6.27E−03	858	0.12	0.07	0.10	675	0.18	0.07	0.01	1,126,428
	YalePenn	0.21	0.05	7.61E−05	858	−0.02	0.06	0.76	675	0.17	0.06	7.28E−03	1,126,428
EA	Indiana Biobank	0.11	0.05	0.02	847	0.02	0.05	0.59	666	0.34	0.05	2.35E−21	1,061,130

Significant P-values are in bold.

PRS_gene PRS calculated using concordant variants located in genes associated with AUD in both AA and EA, PRS_intergenic PRS calculated using concordant variants located outside genes associated with AUD in both AA and EA, PRS_all PRS calculated using all variants.

^aCOGA, SAGE, and YalePenn combined.