Table 2.

Piezo2 channel in cellular mechanotransduction.

	Cells	Pathway and Function	References
Nervous System	Rat DRG neurons	i. GTP/Piezo2 → Increased RA current amplitude ii. Visceral sensation	170,171
	Mouse DRG neurons	i. Epac1/Piezo2 → Allodynia ii. Touch sensation iii. STOML3/cholesterol → Control the membrane mechanics → Sensitivity of Piezo2 → Tactile allodynia iv. Proprioception→Skeletal integrity vi. Mtmr2/PIP2 → Decreased RA current→Somatic sensation	62–64,66,172–174
	Mouse MTN neurons	Proprioception	175
	i. Mouse Merkel cells ii. Rat Merkel cells	i. Ca2+/AP → SAI in Aβ-afferent fibers → Touch sensation ii. Itch inhibition	176–178
	Mouse trigeminal ganglion neurons	Tactile pain	179
	Mouse baroreceptor neurons	Piezo1/2 control blood pressure	180
	Rat bone afferent neurons	Bone pain	181
Respiratory System	Mouse nodose sensory neurons and DRG neurons	i. Lung volume regulation and the Hering–Breuer reflex in adult mice ii. Lung expansion and efficient respiration in newborn mice	182
Digestive System	Mouse enterochromaffin cells	5-HT release and epithelial fluid secretion	183,184

The Piezo2 channel exerts physiological effects on the nervous system, respiratory system and digestive system. In the nervous system, the Piezo2 channel might be a key sensor for light touch, pain, and visceral sensation. The Piezo2 and Piezo1 channels of the baroreceptive nerve endings in the carotid sinus coordinate to control blood pressure. In addition, the Piezo2 channel is not only an indispensable sensor for proprioception but also important in maintaining the integrity of bones. Mice lacking Piezo2 will develop scoliosis and hip dysplasia. In the respiratory system, the Piezo2 channel is essential to establish effective breathing in newborn mice and maintain normal breathing in adult mice. The Piezo2 channel might set the mechanosensitivity of enterochromaffin cells and convert mechanical stimulation of the intestinal lumen into the release of serotonin.