Table 1.
Baseline characteristics of 12,609 genotyped participants according to PRS group.
| Characteristic | Low PRS(q1), No. (%) | Medium PRS (q2-q4), No. (%) | High PRS (q5), No. (%) |
|---|---|---|---|
| No. of participants | 2522 | 7565 | 2522 |
| PRS, mean (SD) | 7.24 (0.21) | 7.86 (0.21) | 8.49 (0.22) |
| Family history of colorectal cancer | 311 (12.3) | 1156 (15.3) | 458 (18.2) |
| Sex, female | 1395 (55.3) | 4147 (54.8) | 1391 (55.2) |
| Age at randomisation, years, mean (SD) | 74.9 (4.1) | 75.1 (4.2) | 75.0 (4.2) |
| 70–74 years | 1562 (61.9) | 4563 (60.3) | 1534 (60.8) |
| 75–79 years | 631 (25.0) | 1916 (25.3) | 633 (25.1) |
| 80–84 years | 261 (10.3) | 844 (11.2) | 268 (10.6) |
| 85+ years | 68 (2.7) | 242 (3.2) | 87 (3.4) |
| Smoker - ever | 1131 (44.8) | 3301 (43.6) | 1135 (45.0) |
| Current alcohol consumption | 2028 (80.4) | 6031 (79.7) | 1994 (79.1) |
| History of diabetes | 223 (8.8) | 696 (9.2) | 248 (9.8) |
| Mean body mass index (SD), kg/m2 | 28.1 (4.5) | 28.0 (4.6) | 28.0 (4.5) |
| Randomized to aspirin | 1276 (50.6) | 3768 (49.8) | 1244 (49.3) |
Note: Brackets are for % of the population in that PRS group unless specified.