. Author manuscript; available in PMC: 2023 Jan 5.

Published in final edited form as: Cancer Prev Res (Phila). 2022 Jul 5;15(7):447–454. doi: 10.1158/1940-6207.CAPR-22-0011

Table 2.

Association between PRS and risk of colorectal cancer

	Low PRS	Medium PRS	High PRS	per SD
Cases/Person-year	21/11408	84/33598	38/10981
HR (unadjusted)	Ref	1.36 (0.84–2.19)	1.88 (1.11; 3.21)	1.29 (1.10; 1.52)
HR (adjusted)	Ref	1.32 (0.82; 2.14)	1.85 (1.08; 3.15)	1.28 (1.09; 1.51)

Adjusted model includes covariates for sex, first degree family history of CRC, age at randomisation, smoker (ever), (yes/no), current alcohol intake (yes/no), history of diabetes, BMI and treatment arm. SD=Standard deviation, HR=Hazard ratio, CI=Confidence interval, BMI=Body mass index, PY=Person years.