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. Author manuscript; available in PMC: 2023 Jan 5.
Published in final edited form as: Cancer Res. 2022 Jul 5;82(13):2329–2343. doi: 10.1158/0008-5472.CAN-21-4370

Figure 1. Induction of EMP promotes tumor immune escape.

Figure 1.

EMP is induced by environmental and genomic factors that canonically activate SNAIL, ZEB, and TWIST transcription factor families. Hybrid E/M states mediate tumor immune escape through evading immune cell cytotoxicity and polarizing immune cells to an immunosuppressive phenotype.