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. 2022 May 10;82(13):2485–2498. doi: 10.1158/0008-5472.CAN-22-0804

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 5. Structural impact of G12D and G12V mutations on GTP-bound substate preference. A, Distance distribution within 3P structure between the hydroxyl (OH) atom of residue Y32 and closest γ-phosphate (called here O1G) atom of GTP or GTP analogues, which was used to define hydrogen (H)-bonding subtypes: water-mediated (WM) H-bond, direct H-bond, and no H-bond. 3P substate preference within WT (B), G12D (C), and G12V (D) structures. — Structural impact of G12D and G12V mutations on GTP-bound substate preference. A, Distance distribution within 3P structure between the hydroxyl (OH) atom of residue Y32 and closest γ-phosphate (called here O1G) atom of GTP or GTP analogues, which was used to define hydrogen (H)-bonding subtypes: water-mediated (WM) H-bond, direct H-bond, and no H-bond. B–D, 3P substate preference within WT (B), G12D (C), and G12V (D) structures.