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Summary of Imatinib dissociation kinetics, comparing the residence time/koff of WT and mutant Abl as measured in this work against experiments in Ref. 69
| System | Infreq Metad residence time (sec) | Infreq. Metad. koff (sec−1) | Experimental residence time (sec) | Experimental koff (sec−1) | p-value |
|---|---|---|---|---|---|
| Wild-type | 1600± 800 | 6± 3 e-04 | 1200± 120 | 8.3± .83 e-04 | 0.11 |
| N368S | 300± 200 | 4± 2 e-03 | 370± 37 | 2.7± .27 e-03 | 0.23. |
