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. 2022 Jun 2;18:552–568. doi: 10.1016/j.bioactmat.2022.05.023

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Angiogenesis and inflammatory response at the wound site following treatment with nanohybrids at different time points. (A) Immunohistochemical staining of CD31 and co-location of CD31 and α-SMA immunofluorescence staining in the skin defect area at 5 and 9 days postoperatively. Scale bar: 50 μm. (B) Quantitative analysis of the number of newly-formed blood vessels and mature blood vessels in the control group and QCS/5QCS-1GO/5QCS-1GO-PDA at 5 and 9 days after operation. (C) CD68 immunofluorescence staining of the wound site in different treatment groups 5 days after surgery. Scale bar: 200 μm. Data are represented as mean ± SD (n = 3, *p < 0.05, **p < 0.01).