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. 2022 Jun 22;13:927824. doi: 10.3389/fendo.2022.927824

Figure 1.

Figure 1

A schematic of AMH and AMHR2 processing and receptor assembly. (A) The full translated sequences of AMH and AMHR2 undergo processing to cleave the signal sequence. In AMH, PCs will cleave at the solid bar, separating the prodomain and mature domain, while alternative processing may occur at the dashed bar. In AMHR2, dashed bars represent alternative splicing sites. (B) Assembled AMH pro-complex, which may or may not be cleaved. (C) AMH-driven receptor assembly at the cell surface, resulting from AMH binding AMHR2 and prodomain dissociation. Type I receptors are activated and in turn activate BMP R-Smads.