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. 2022 Jun 22;13:876048. doi: 10.3389/fimmu.2022.876048

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Copyright © 2022 Kong, Zheng, Song, Zhang, Liu, Kang, Sun, Sun, Huang, Li, Rong, Wang, Tang and Xia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amoxapine decreased the proliferation, invasion, and migration of human HCC cells by inhibiting GUSB and upregulating PD-L1 expression in HCC. (A) The growth curves of cells were plotted after adding DMSO or amoxapine based on the CCK-8 assay. (B) EdU assay was performed to assess cell proliferation of HCC cells added with DMSO or amoxapine. Scar bar, 50 um. (C) Transwell invasion assay was performed to assess invasion of HCC cells added with DMSO or amoxapine. Scar bar, 100 um. (D) A Scratch assay was performed to assess the migration of HCC cells added with DMSO or amoxapine. Scar bar, 250 um. (E, F) The protein expression of PD-L1 in HCC cells was added with DMSO or amoxapine. Panel (E) represents the variation of protein bands, and Panel (F) illustrates the protein gray value analysis. Each experiment was repeated three times. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001.