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. 2022 Jun 22;13:876048. doi: 10.3389/fimmu.2022.876048

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Copyright © 2022 Kong, Zheng, Song, Zhang, Liu, Kang, Sun, Sun, Huang, Li, Rong, Wang, Tang and Xia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Amoxapine worked as an effective means to treat HCC and improved the sensitivity of anti-PD1 therapy. (A) Schematic diagram of animal experiment. we injected Hepa1–6 cells in C57BL/6 mice. (B–D) The volume (B, C) and weight (D) statistics of subcutaneous tumors in the respective groups (PBS, amoxapine, anti-PD1, amoxapine + anti-PD1). (E) Immunohistochemistry result of CD8, Ki67, PD1, and PD-L1 expression in the respective groups. Scar bar, 50 um. *P < 0.05; **P < 0.01; ***P < 0.0001; ****P < 0.0001.