TABLE 4.
Correlation between genetic polymorphisms and adverse reactions.
| Adverse reactions | Gene | SNP-ID | Genotype | Abnormal group (n) | Normal group (n) | p value | OR | 95%CI |
|---|---|---|---|---|---|---|---|---|
| Hypertension | CYP2C19 | rs3814637 | CC | 21 (0.179) | 96 (0.821) | — | — | — |
| TT+CT | 9 (0.409) | 13 (0.591) | 0.034 a | 0.316 | 0.12–0.84 | |||
| rs11568732 | TT | 9 (0.409) | 13 (0.591) | — | — | — | ||
| GT+GG | 21 (0.179) | 96 (0.821) | 0.034 a | 0.316 | 0.12–0.84 | |||
| CYP3A4 | rs2242480 | CC | 17 (0.227) | 58 (0.773) | — | — | — | |
| CT+TT | 13 (0.203) | 51 (0.797) | 0.737 | 0.87 | 0.39–1.96 | |||
| rs3735451 | TT | 13 (0.206) | 49 (0.794) | — | — | — | ||
| CC+CT | 17 (0.224) | 60 (0.776) | 0.874 | 0.936 | 0.42–2.12 | |||
| rs4646437 | GG | 22 (0.206) | 85 (0.794) | — | — | — | ||
| AG+AA | 8 (0.250) | 24 (0.750) | 0.592 | 0.776 | 0.31–1.96 | |||
| rs4646440 | GG | 18 (0.228) | 61 (0.772) | — | — | — | ||
| AA+AG | 12 (0.200) | 48 (0.800) | 0.693 | 0.847 | 0.37–1.93 | |||
| CYP3A5 | rs1419745 | TT | 14 (0.209) | 53 (0.791) | — | — | — | |
| CC+CT | 16 (0.222) | 56 (0.778) | 0.849 | 0.925 | 0.41–2.08 | |||
| rs15524 | AA | 13 (0.206) | 50 (0.794) | — | — | — | ||
| GG+AG | 17 (0.224) | 59 (0.776) | 0.805 | 1.108 | 0.49–2.50 | |||
| rs3800959 | AA | 22 (0.237) | 71 (0.763) | — | — | — | ||
| AG+GG | 8 (0.174) | 38 (0.826) | 0.398 | 0.679 | 0.28–1.67 | |||
| rs4646450 | GG | 14 (0.209) | 53 (0.791) | — | — | — | ||
| AG+AA | 16 (0.222) | 56 (0.778) | 0.849 | 1.082 | 0.48–2.43 | |||
| Hemoptysis | CYP2C19 | rs11568732 | TT | 2 (0.025) | 77 (0.975) | — | — | — |
| (Peripheral lung cancer) | GT+GG | 3 (0.167) | 15 (0.833) | 0.043 a | 0.13 | 0.02–0.85 | ||
| rs3814637 | CC | 2 (0.025) | 77 (0.975) | — | — | — | ||
| CT+TT | 3 (0.167) | 15 (0.833) | 0.043 a | 0.13 | 0.02–0.85 | |||
| CYP3A4 | rs2242480 | CC | 2 (0.041) | 47 (0.959) | — | — | — | |
| CT+TT | 3 (0.063) | 45 (0.938) | 0.981 | 0.638 | 0.10–4.00 | |||
| rs3735451 | TT | 2 (0.050) | 38 (0.950) | — | — | — | ||
| CC+CT | 3 (0.053) | 54 (0.947) | 1.000 | 0.947 | 0.15–5.95 | |||
| rs4646437 | GG | 4 (0.056) | 68 (0.944) | — | — | — | ||
| AG+AA | 1 (0.040) | 24 (0.960) | 1.000 | 1.412 | 0.15–13.26 | |||
| rs4646440 | GG | 2 (0.038) | 50 (0.962) | — | — | — | ||
| AA+AG | 3 (0.067) | 42 (0.933) | 0.868 | 0.560 | 0.09–3.51 | |||
| CYP3A5 | rs1419745 | TT | 2 (0.048) | 40 (0.952) | — | — | — | |
| CC+CT | 3 (0.055) | 52 (0.945) | 1.000 | 0.867 | 0.14–5.44 | |||
| rs15524 | AA | 2 (0.049) | 39 (0.951) | — | — | — | ||
| GG+AG | 3 (0.054) | 53 (0.946) | 1.000 | 0.906 | 0.14–5.68 | |||
| rs3800959 | AA | 5 (0.070) | 66 (0.930) | — | — | — | ||
| AG+GG | 0 (0.000) | 26 (1.000) | 0.384 | 0.93 | 0.87–0.99 | |||
| rs4646450 | GG | 2 (0.048) | 40 (0.952) | — | — | — | ||
| AG+AA | 3 (0.055) | 52 (0.945) | 1.000 | 0.867 | 0.14–5.44 | |||
| Hemoptysis | CYP2C19 | rs11568732 | TT | 6 (0.158) | 32 (0.842) | — | — | — |
| (central lung cancer) | GT+GG | 1 (0.250) | 3 (0.750) | 0.532 | 0.563 | 0.05–6.36 | ||
| rs3814637 | CC | 6 (0.158) | 32 (0.842) | — | — | — | ||
| CT+TT | 1 (0.250) | 3 (0.750) | 0.532 | 0.563 | 0.05–6.36 | |||
| CYP3A4 | rs2242480 | CC | 3 (0.115) | 23 (0.885) | — | — | — | |
| CT+TT | 4 (0.250) | 12 (0.750) | 0.447 | 0.391 | 0.08–2.04 | |||
| rs3735451 | TT | 3 (0.136) | 19 (0.864) | — | — | — | ||
| CC+CT | 4 (0.200) | 16 (0.800) | 0.89 | 0.632 | 0.12–3.25 | |||
| rs4646437 | GG | 6 (0.171) | 29 (0.829) | — | — | — | ||
| AG+AA | 1 (0.143) | 6 (0.857) | 1.000 | 1.241 | 0.13–12.29 | |||
| rs4646440 | GG | 3 (0.111) | 24 (0.889) | — | — | — | ||
| AA+AG | 4 (0.267) | 11 (0.733) | 0.388 | 0.344 | 0.07–1.81 | |||
| CYP3A5 | rs1419745 | TT | 3 (0.120) | 22 (0.880) | — | — | — | |
| CC+CT | 4 (0.235) | 13 (0.765) | 0.574 | 0.443 | 0.09–2.30 | |||
| rs15524 | AA | 3 (0.136) | 19 (0.864) | — | — | — | ||
| GG+AG | 4 (0.200) | 16 (0.800) | 0.890 | 0.632 | 0.12–3.25 | |||
| rs3800959 | AA | 4 (0.182) | 18 (0.818) | — | — | — | ||
| AG+GG | 3 (0.150) | 17 (0.850) | 1.000 | 1.259 | 0.25–6.47 | |||
| rs4646450 | GG | 3 (0.120) | 22 (0.880) | — | — | — | ||
| AG+AA | 4 (0.235) | 13 (0.765) | 0.574 | 0.443 | 0.09–2.30 |
a
Significant at p < 0.05. OR, odd ratio; 95%CI, 95%confidence interval.