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. 2022 Jun 22;12:911259. doi: 10.3389/fcimb.2022.911259

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Copyright © 2022 Liu, Liu, Gao, Zhou, Gao, Luo, Liu and Fan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GW4064 treatment did not alter exploratory locomotion and anxiety in the open field test. (A) The representative traces of different groups of mice in the open field test. (B) The activity was measured as the total amount of distance traveled. The BTBR mice showed a stronger exploratory locomotion ability than C57 mice. (D) BTBR mice spent less time in the center in the open field test, and the total time of the 30-minute test in the center was not affected by GW4064 treatment in C57 and BTBR mice. (C, E) A 30-minute assay of distance moved (C) and time in the center (E) were computationally split into six segments with 5 minute per segment. The GW4064 treatment did not have effects on distance traveled and time spent in the center for each 5-minute segment in BTBR mice. The data are presented as the mean ± SEM. n = 10. **p < 0.01; ***p < 0.001.