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. 2022 Jun 22;12:911259. doi: 10.3389/fcimb.2022.911259

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Copyright © 2022 Liu, Liu, Gao, Zhou, Gao, Luo, Liu and Fan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GW4064 treatment significantly modulated the decreased gut microbiota diversity in BTBR mice. (A) GW4064 treatment altered the alpha-diversity in BTBR mouse gut microbiota analyzed with Chao1, Shannon, Observed-species index to a similar level of C57. (B–D) GW4064 treatment altered the BTBR gut microbiota principal coordinate analysis (PCoA) of the beta-diversity index to get close to C57 using Bray-Curtis(B), unweighted-unifrad(C), weighted-unifrad distances(D). Each symbol represents an individual mouse. n = 7. *p < 0.05, **p < 0.01, ***p < 0.001 (E–G) PERMANOVA statistical tests quantify the distances among groups corresponding to the Bray-Curtis(E), unweighted-unifrad (F), weighted-unifrad distances (G).