FIG. 4.

Alignment of the methyltransferase domain of CmuA from H. chloromethanicum CM2^T with CmuA from M. chloromethanicum CM4^T and MtbA and MtsA from M. barkeri. CmuA from H. chloromethanicum CM2^T was aligned with CmuA from M. chloromethanicum CM4^T (accession no. AJ011316) and with MtbA (U38918) and MtsA (U36337) from M. barkeri. Aligned sequences in GCG's MSF format were downloaded into the BoxShade 3.21 vs program, which highlighted similar residues (shaded boxes) and identical residues (black boxes). Asterisks indicate the putative zinc-binding motif identified in MtbA from M. barkeri (25).