TABLE 3.

Summary of neuroprotective and neurotoxic effects of oligodendrocytes and Schwann cells-derived exosomes with identified cargo.

Role	Stimuli/disease	Cargo	Effect observed	References
Neurotoxic	PLP and CNP deficiency	Decreased PLP levels	Reduces axonal transport under nutrient deprivation	Frühbeis et al., 2020
	Polarization into repair phenotype with forskolin	MiR-21	Increases axonal regeneration	López-Leal and Díaz-Viraqué, 2020
Neuroprotective	OGD	SOD and catalase	Increases metabolic rate and neuroprotection under oxidative stress	Frohlich et al., 2014
	–	Myelin antigen	Decreases neuroinflammation, demyelination and axonal damage	Casella et al., 2020
Neuroprotective in a EAE model	IL-4	miR-124	Protects neurons from OGD induced cell death	Song et al., 2019
Regulatory	–	PLP, CNP	Inhibits myelination of neurons	Krämer-Albers et al., 2007