FIGURE 1.

Overview of expression, diagnostic, and prognostic values of m⁵C regulators in breast cancer. (A) Diagram of m⁵C regulators. (B) Expression of m⁵C regulators in TCGA breast cancer cohort. Blue: normal samples; red: cancer samples. (C) Expression of m⁵C regulators determined by the Oncomine database. (D) Survival analysis (including overall survival and relapse-free survival) for m⁵C regulators in breast cancer using the Kaplan–Meier plotter. (E) Prognostic values of DNMT3B in breast cancer. (F) Prognostic values of ALYREF in breast cancer. (G) ROC curve of DNMT3B in breast cancer. (H) ROC curve of ALYREF in breast cancer. The protein level of DNMT3B (I) or ALYREF (J) in breast cancer detected by Human Protein Atlas database. Scale bar: 100 um. (K) Expression of DNMT3B in breast cancer among various stages. (L) Expression of ALYREF in breast cancer among various stages. (M) (I) Expression of DNMT3B and ALYREF across different cancer types by the Oncomine database. **p < 0.01; ***p < 0.001.