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. 2022 Jul 6;76:102439. doi: 10.1016/j.sbi.2022.102439

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© 2022 The Author(s)

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Representative example of heparan sulfate (HS) structure, sulfation pattern and 3D spatial geometry. Top panel: The SNFG representation of an HS 18-mer connected to the tetrasaccharide (glucuronic acid-galactose-galactose-xylose) linker that is attached to HSPG core protein (HSPG core protein shown in purple) [19, 19]. A potential binding site for a fibroblast growth factor receptor and the high affinity binding site for antithrombin is indicated. Bottom panel: a molecular model, shown in stick form and in a biologically relevant conformation, reflecting the oligosaccharide in the top panel.