Figure 2.

Global and SHF-specific deletion of Agtr1a result in improved histopathology. Representative sections of VVG-stained aortic roots and quantification of elastic fiber content relative to cellular area for female (A,B) and male (C,D) samples of indicated genotypes. Three representative images are shown per genotype for each sex. Images are shown at 20 × magnification. Scale bar is 50 μm. Quantification of elastic fiber content relative to cellular area is shown in (C) for female samples, and in (D) for male samples, with higher value indicating a greater content of elastic fiber per area unit. The number of mice scored per group is indicated. P-values refer to Brown-Forsythe ANOVA, followed by post-hoc test with multiple comparison FDR correction.