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. 2022 Jun 22;12:930647. doi: 10.3389/fonc.2022.930647

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Copyright © 2022 Nie, Pu, Han, Wang, Pan, Li, Ma, Yao, Zhao, Wang, Jiang and Ding

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ESPL1 knockdown inhibited cell migration and invasion of LUAD. (A, B) IHC assay used to determine the protein of ESPL1 in clinical lung cancer samples. (C) The relative expression of ESPL1 in LUAD cell lines including H1650, H358, A549, and H1299 examined by real-time RT-PCR and human bronchial epithelial (BEAS2B) cell line was used as control. (D) Establishment of ESPL1 knockdown in A549 and H1299 cells, verified by real-time RT-PCR. (E–H) Downregulation of ESPL1 inhibited A549 and H1299 cell migration and invasion by transwell and wound healing assays, Quantification data were also indicated for each assay. Scale bar = 50 μm. **p < 0.01; ***p < 0.001.