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. 2022 Jun 9;298(7):102116. doi: 10.1016/j.jbc.2022.102116

Figure 2.

Figure 2

miR-134-5p expression was decreased in an ovariectomized (OVX) mouse model.A, microarray profiling analysis was performed, and 181 significantly differentiated miRNAs were discovered in the samples (|log2FC| ≥ 1 and p value < 0.05). B, heatmap displaying the differentially expressed miRNAs in the samples of sham and OVX mice. C, volcano plot diagram showing the significantly upregulated or downregulated miRNAs. D, scatter plot diagram revealing the correlation among the significantly differentially expressed miRNAs. E, a Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was performed to determine the top related pathways involving these differentially expressed miRNAs. F and G, the expression level of miR-134-5p in bone tissue and in BMMs of the sham and OVX groups was determined. U6 was used as an internal reference gene. All the data are expressed as the means ± SDs. ∗p < 0.05, ∗∗p < 0.01. BMMs, bone marrow macrophages.