TABLE 3.

Linear regression coefficients of vascular factors and brain MRI measures

			NODDI free water WM				Fractional anisotropy WM				White matter hyperintensity volume				Gray matter cerebral blood flow				White matter cerebral blood flow
			(n = 415)				(n = 438)				(n = 455)				(n = 423)				(n = 423)
		N	beta	SE	P‐value	N	beta	SE	P‐value	N	beta	SE	P‐value	N	beta	SE	P‐value	N	beta	SE	P‐value
cfPWV (m/s)	Model 1	415	0.205	0.046	<.001	438	−0.109	0.051	0.034	455	0.101	0.043	0.021	424	−0.062	0.047	0.194	423	0.026	0.052	0.616
	Model 2	410	0.183	0.047	<.001	433	−0.099	0.052	0.058	450	0.079	0.044	0.077	418	−0.040	0.048	0.410	418	0.053	0.053	0.317
SBP (mmHg)	Model 1	410	0.140	0.046	0.003	433	−0.095	0.049	0.053	450	0.102	0.041	0.013	418	−0.106	0.045	0.020	418	−0.107	0.050	0.032
	Model 2	410	0.093	0.046	0.045	433	−0.065	0.050	0.195	450	0.083	0.043	0.055	418	−0.087	0.046	0.062	418	−0.107	0.051	0.035

Notes: Model 1 adjusted for age, sex, race, and education. Model 2 adjusted for age, sex, race, education, and hypertension treatment, with SBP and cfPWV in the model together. Regression coefficients correspond to change in cognitive test performance corresponding to a one SD increase in PWV or SBP.

Abbreviations: cfPWV, carotid‐femoral pulse wave velocity; NODDI, neurite orientation density and dispersion imaging; SBP, systolic blood pressure; SD, standard deviation; SE, standard error; WM, white matter.