NAFLD/NASH leading to PVT. The independent pathogenesis of NAFLD/NASH creates a proinflammatory and prothrombotic state, which not only creates an environment favoring thrombosis including PVT. Adapted from Targher et al. (7). NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; CRP, C-reactive protein; vWF, von Willebrand factor; PVT, portal vein thrombosis.