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. 2022 Jul 6;5:669. doi: 10.1038/s42003-022-03630-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Means of the number of infectious units of virus for the SARS-CoV-2 spike Omicron variants (n = 3). Human osteosarcoma (HOS) cells expressing ACE2 and TMPRSS2 infected with HIV-based pseudotyped virus were assessed. Relative infection units at the indicated concentrations of the P86 (black) and sotrovimab (grey) are plotted; means ± standard deviation (SD) are shown. Measured IC₅₀s for the SARS-CoV-2 Omicron variants BA.1 and BA.2 of P86 and sotrovimab are inset. b, c Concentration dependency of the P86 nanobody (b) and sotrovimab antibody (c) for plaque reduction of the authentic SARS-CoV-2 Omicron BA.1 variant virus. The ratios of plaque formation are expressed as a percentage of the plaque numbers from untreated cells and fitted with a sigmoidal function using Igor Pro (ver. 8.04, Wavemetrics). Data are representative of two independent experiments. d The C246 nanobody versus plaque formation of the authentic Wuhan and Omicron BA.1 variant viruses. The ratios of plaque formation are shown as a percentage of the plaque numbers from untreated cells (n = 1).