Fig. 5. In vivo SPECT imaging of EpCAM-specific DARPins probes. Notes: OVCAR-3 (A) and SKOV-3(B) xenografts models; mice are injected with the DARPin probe [125I] I-PIB-Ec1 and imaged at 6 hours post-injection. High contrast tumor imaging and mainly cleared through the kidneys has shown. Adapted from ref. 123. Abbreviations: SPECT, Single-photon emission computed tomography; EpCAM, epithelial cell adhesion molecules; DARPins, designed ankyrin repeat proteins; K, kidneys; and T, tumors.
