Triple-positive breast carcinoma and associated DCIS in pretreatment core biopsy (A) shows strong and diffuse staining for (B) ER and (C) PR, and (D) 3+ HER2 staining. E, Postneoadjuvant excision shows residual invasive carcinoma with treatment effect and positive staining with (F) ER, (G) PR, and (H) HER2 (hematoxylin-eosin, original magnification×10 [A and E]; original magnification ×10 [B, C, D, F, G, and H]). Abbreviations: DCIS, ductal carcinoma in situ; ER, estrogen receptor; PR, progesterone receptor.