Table 1.
Clinical and Histomorphologic Features of Studied Patients and Hormone Receptor and HER2 Results Determined in Pretreatment Core Biopsies
| Characteristic | No. | % |
|---|---|---|
| Age, median (range) | 47 (26–70) | |
| Clinical T stage | ||
| cT1 | 14 | 16.5 |
| cT2 | 58 | 68.2 |
| cT3 | 9 | 10.6 |
| cT4 | 4 | 4.7 |
| Nodal status | ||
| Positive | 50 | 58.9 |
| Negative | 35 | 41.1 |
| Histologic type | ||
| Ductal | 81 | 95.3 |
| Lobular | 3 | 3.5 |
| Mixed ductal and lobular | 1 | 1.2 |
| Histologic grade | ||
| 2 | 43 | 50.6 |
| 3 | 42 | 49.4 |
| ER IHC (H-score) | ||
| 0–100 | 12 | 14.1 |
| 101–200 | 19 | 22.4 |
| 201–300 | 54 | 63.5 |
| PR IHC (H-score) | ||
| 0–100 | 35 | 41.2 |
| 101–200 | 17 | 20 |
| 201–300 | 33 | 38.8 |
| HER2 IHC/FISH | ||
| IHC 0/1 + | 5 | 5.9 |
| HER2/CEP17 ratio, mean (range) | 2.46 (2.3–2.9) | |
| HER2 signals/cell, mean (range) | 6.32 (4.6–9.3) | |
| IHC 2+ | 28 | 33 |
| FISH ratio, mean (range) | 3.41 (2–9.6) | |
| HER2 signals/cell, mean (range) | 7.28 (4.1–18.4) | |
| IHC 3+ | 52 | 61.1 |
| FISH ratio, mean (range) | 5.93 (3–12.2) | |
| HER2 signals/cell, mean (range) | 15 (7.1–30.4) |
Abbreviations: ER, estrogen receptor; FISH, fluorescence in situ hybridization; HER2, human epidermal growth factor receptor type 2; IHC, immunohistochemistry; PR, progesterone receptor.