Figure 2.

Scatter plots showing the predictions for clearance after IV dosing using six different scaling methods. Observed PK parameters are plotted on the x axis while predicted parameters are on the y axis. Solid black line represent the line of unity; blue dashed line and red dotted lines represent 2- and 3-fold errors, respectively; blue solid line and shaded gray area represent a linear regression and its 95% confidence interval; and the high and moderate protein binding category compounds are represented by circles and triangles, respectively.