TABLE 1.

Baseline characteristics of participants with positive and negative rechallenge following anti-tuberculosis drug-induced liver injury.

Baseline characteristics	Positive rechallenge (n = 14)	Negative rechallenge (n = 65)	All rechallenged participants (n = 79)	P *
Age (years)				0.368
Mean ± s.d.	35 ± 12	38 ± 9	37 ± 10
Female				0.039
n	11	30	41
%	79	46	52
Weight (kg)				0.418
Median	59	54	54
IQR	50–74	46–64	47–64
First time on TB treatment				0.032
n	14	47	61
%	100	72	77
HIV-positive				0.075
n	10	58	68
%	71	89	86
CD4 count (cells/mm3) (for HIV-positive)†				0.646
Median	56	76	70
IQR	4–277	26–144	26–144
ALT (U/L)				0.090
Median	255	385	357
IQR	225–352	279–558	254–558
Total bilirubin (mmol/L)				0.767
Median	44	49	47
IQR	26–81	21–94	22–90
ALP (U/L)				0.245
Median	126	183	175
IQR	101–194	112–258	110–254
INR ‡				0.288
Median	1.1	1.3	1.2
IQR	1.0–2.1	1.1–1.8	1.1–1.8
Albumin g/L§				0.758
Median	26	26	26
IQR	19–35	21–30	21–30

ALT, alanine transferase; ALP, alkaline phosphatase; INR, international normalised ratio; IQR, interquartile range; s.d., standard deviation; TB, tuberculosis.

^*, Fisher’s exact test for categorical variables, t-test for parametric data, rank sum test for non-parametric data.

^†, 26 with missing data.

^‡, 5 with missing data.

^§, 5 with missing data.